Recommanded Product: 3-Phenylprop-2-yn-1-ol, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 1504-58-1, Name is 3-Phenylprop-2-yn-1-ol, SMILES is OCC#CC1=CC=CC=C1, belongs to isothiazole compound. In a article, author is de Vicente, Javier, introduce new discover of the category.
A series of benzo[d]isothiazole-1,1-dioxides were designed and evaluated as inhibitors of HCV polymerase NS5B. Structure-based design led to the incorporation of a high affinity methyl sulfonamide group. Structure-activity relationship (SAR) studies of this series revealed analogues with submicromolar potencies in the HCV replicon assay and moderate pharmacokinetic properties. SAR studies combined with structure based drug design focused on the sulfonamide region led to a novel and potent cyclic analogue. (C) 2009 Elsevier Ltd. All rights reserved.
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 1504-58-1, Recommanded Product: 3-Phenylprop-2-yn-1-ol.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com