New Advances in Chemical Research in 2021, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 3466-32-8, Name is 1-Bromo-4-(methylsulfonyl)benzene, molecular formula is C7H7BrO2S, belongs to isothiazole compound. In a document, author is Hermit, MB, introduce the new discover, Formula: https://www.ambeed.com/products/3466-32-8.html.
In this study, we have determined and compared the pharmacological profiles of ibotenic acid and its isothiazole analogue thioibotenic acid at native rat ionotropic glutamate (iGlu) receptors and at recombinant rat metabotropic glutamate (mGlu) receptors expressed in mammalian cell lines. Thioibotenic acid has a distinct pharmacological profile at group III mGlu receptors compared with the closely structurally related ibotenic acid; the former is a potent (low mum) agonist, whereas the latter is inactive. By comparing the conformational energy profiles of ibotenic and thioibotenic acid with the conformations preferred by the ligands upon docking to mGlu(1) and models of the other mGlu subtypes, we propose that unlike other subtypes, group III mGlu receptor binding sites require a ligand conformation at an energy level which is prohibitively expensive for ibotenic acid, but not for thioibotenic acid. These studies demonstrate how subtle differences in chemical structures can result in profound differences in pharmacological activity. (C) 2004 Elsevier B.V. All rights reserved.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 3466-32-8, Formula: https://www.ambeed.com/products/3466-32-8.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com