Chemical Research Letters, April 2021. Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 398489-26-4, Name is tert-Butyl 3-oxoazetidine-1-carboxylate, molecular formula is C8H13NO3, HPLC of Formula: https://www.ambeed.com/products/398489-26-4.html, belongs to isothiazole compound, is a common compound. In a patnet, author is Amirhamzeh, Amirali, once mentioned the new application about 398489-26-4.
Neuroinflammation has been implicated in pathophysiology of many neurodegenerative diseases. The p38 MAP kinase signaling pathway and COX-1 have active roles in initiation and perpetuation of neuroinflammatory process which have deteriorating effects on neurons. In order to develop new anti-neuroinflammatory compounds some 4-aryl-5-(methylthiophen-2-yl) isothiazoles and 5-aryl-4-(methylthiophen-2-yl)-1,2,3-thiadiazoles were synthesized. Docking studies have revealed that these structures could be potential mutual inhibitors of p38 alpha and COX-1 and could be considered for neuroprotective effects. In order to assess CNS penetrability of these compounds, a QSAR model of blood-brain barrier penetration has been developed and LogBB of compounds has been predicted. All compounds showed LogBB as greater than zero which indicates their potential CNS penetrability.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. In my other articles, you can also check out more blogs about 398489-26-4. HPLC of Formula: https://www.ambeed.com/products/398489-26-4.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com