New Advances in Chemical Research, April 2021. Recommanded Product: (4-Fluorophenyl)methanol, Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 459-56-3, Name is (4-Fluorophenyl)methanol, SMILES is OCC1=CC=C(F)C=C1, belongs to isothiazole compound. In a article, author is Lipnicka, Urszula, introduce new discover of the category.
Several new derivatives of 5-hydrazino-3-methyl-4-isothiazolecarboxylic ethyl esters were synthesized. Using 4-aminoacetophenone, the hydrazine group was transformed in position 5 in the hydrazone which reacted with the isocyanates, aldehydes and sugars. Thirteen newly synthesized compounds were tested for their ability to affects the immunological response in vitro in several rodent models. The immunoregulatory properties of the compounds were, differential and dose-dependent, The strongest activity was exhibited by 5-{N’-[1-4}-4-[3-(-methoxyphenyl)-ureido]-phenylethylidene]-hydrazino}-3-methyl-4-isothiazolecarboxylic acid ethyl ester (compound 3a). The compound strongly inhibited the secondary, humoral immune response to sheep erythrocytes and the proliferative response of mouse splenocytes to concanavalin A and pokeweed mitogen. The immunotropic activities of the new isothiazole derivatives and potential application of the compounds in therapy are discussed.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com