New Advances in Chemical Research in 2021. SDS of cas: 127-63-9, You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. 127-63-9, Name is Sulfonyldibenzene, SMILES is O=S(C1=CC=CC=C1)(C2=CC=CC=C2)=O, belongs to isothiazole compound. In a article, author is Bunch, L, introduce new discover of the category.
Direct functionalization of the 3-oxygenated isothiazole heteroaromatic parental system has not yet been reported in the literature. Here, we report the first regioselective lithiation of the 5-position of 3-(benzyloxy)isothiazole (4) using LDA in diethyl ether. The versatility of the methodology was explored by quenching with a variety of electrophiles to give the desired products 7a,b,d-g in 54-68% yield. Only benzoylation aiming at the synthesis of 7c was unsuccessful. Furthermore, a highly convergent synthesis of thioibotenic acid (1), the sulfur analogue of the neurotoxic natural product ibotenic acid, was carried out.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com