New Advances in Chemical Research in 2021, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 121-89-1, Name is 3′-Nitroacetophenone, molecular formula is C8H7NO3, belongs to isothiazole compound. In a document, author is SWAYZE, EE, introduce the new discover, Recommanded Product: 3′-Nitroacetophenone.
Several derivatives of the new imidazo[4,5-d]isothiazole ring system have been synthesized from the appropriately substituted isothiazolediamines. The reaction of 3-methyl-4,5-diaminoisothiazole (4a) with diethoxy-methyl acetate gave a low yield of 3-methylimidazo[4,5-d]isothiazole (5a). However, the analogous reaction of 4,5-diaminoisothiazole (4b) with diethoxymethyl acetate failed to yield the parent imidazo[4,5-d]isothiazole ring system. The diamines 4a and 4b were readily cyclized with thiocarbonyldiimidazole to give the unstable thiones 6a and 6b, which were alkylated in situ to afford good yields of the corresponding 5-methylthioimidazo[4,5-d]isothiazoles 7a and 7b, respectively. Neither of these compounds could be reduced to the corresponding 5-unsubstituted derivatives via treatment with Raney nickel. To the best of our knowledge, this is the first report of the imidazo[4,5-d]isothiazole ring system.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 121-89-1, Recommanded Product: 3′-Nitroacetophenone.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com