Chemical Research Letters, April 2021. With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation we’ve spent the past two centuries establishing. 1775-95-7, Name is (2-Amino-5-nitrophenyl)(phenyl)methanone, molecular formula is C13H10N2O3, Safety of (2-Amino-5-nitrophenyl)(phenyl)methanone, belongs to isothiazole compound, is a common compound. In a patnet, author is Metz, Clyde R., once mentioned the new application about 1775-95-7.
Dilithiated C(alpha), N-carbomethoxyhydrazones were condensed with lithiated methyl 2-(aminosulfonyl)benzoate to afford intermediates that were isolated and not characterized but cyclized with acetic anhydride, which also resulted in N-acetylation. The X-ray crystal structure determinations of methyl 2-acetyl-5′-phenyl-2H-spiro[benzo[d]isothiazole-3,3′-pyrazole]-1,1-dioxide-2′(4’H)-carboxylate and methyl 2-acetyl-5′-(2-thienyl)-2H-spiro[benzo [d]isothiazole-3,3′-pyrazole]-1,1-dioxide-2′(4’H)-carboxylate products were a follow up for absorption spectra, and they confirmed their structures. Mechanistic intermediates to describe the reaction may include C-acylated intermediates that cyclize to spiro(N-benzoisothiazole dioxide-pyrazole) instead of N-carbomethoxypyrazole-ortho-benzenesulfonamides. Crystals of C19H17N3O5S 7 are monoclinic, P2(1)/c, a = 11.899(2) angstrom, b = 17.562(4) angstrom, c = 9.484(2) angstrom, beta = 111.03(3)degrees, Z = 4, V = 1849.9(6) angstrom(3), R-1 = 0.0857 and wR(2) = 0.2216 for reflections with I > 2 sigma(I); crystals of C17H15N3O5S2 8 are orthorhombic, Pbca, a = 16.045(3) angstrom, b = 10.746(2) angstrom, c = 20.389(4) angstrom, Z = 8, V = 3516(1) angstrom(3), R-1 = 0.0841 and wR(2) = 0.2179 for all reflections with I sigma 2 sigma(I).
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 1775-95-7, Safety of (2-Amino-5-nitrophenyl)(phenyl)methanone.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com