Chemical Research Letters, April 2021. With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation we’ve spent the past two centuries establishing. 127-63-9, Name is Sulfonyldibenzene, molecular formula is C12H10O2S, Product Details of 127-63-9, belongs to isothiazole compound, is a common compound. In a patnet, author is Stachel, HD, once mentioned the new application about 127-63-9.
The 1,2-dithiolosultam derivative 14 was obtained from the (alpha-bromoalkylidene)propenesultam derivative 9 (Scheme 1). Regioselective cleavage of the two ester groups ( -> 1b or 2b) allowed the preparation of derivatives with different substituents at C(3) in the dithiole ring (see 27 and 28) as well as at C(6) in the isothiazole ring (see 17 – 21; Scheme 2). Curtitis rearrangement of the 6-carbonyl azide 21 in Ac2O afforded the 6-acetamide 22, and saponification and decarboxylation of the latter yielded ‘sulfothiolutin’ (30). Hydride reductions of two of the bicyclic sultams resulted in ring opening of the sultam ring and loss of the sulfonyl group. Thus the reduction of the dithiolosultam derivative 14 yielded the alkylidenethiotetronic acid derivative 33 (tetronic acid = furan-2,4(3H,4H)-dione), and the lactam-sultam derivative 10 gave the alkylidenctetramic acid derivative 35 (tetramic acid= 1,5-dihvdro-4-hydroxy-2H-pyrrol-2-one) (Scheme 3). Some of the new compounds (14, 22, 26, and 30) exhibited antimycobacterial activity. The oxidative addition of 1 equiv. of [pt(eta(2)-C2H4)L-2] (36a, L – PPh3; 36b, L = 1/2 dppf; 36c, L = 1/2 (R,R)-diop) into the S-S bond of 14 led to the cis(dithiolato)platinum(II) complexes 37a-c. (dppf=1,1′-bis(diphenylphosphino)ferrocene; (R,R)-diop([(4R,5R)-2,2-demithyl-1,3-dioxolane-4,5-diyl]bis(iiiethylene)bis(diphenylphosphine]).
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 127-63-9, Product Details of 127-63-9.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com