Electric Literature of 18621-17-5, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 18621-17-5, Name is 1-Benzhydrylazetidin-3-ol, SMILES is C3=C(C(N1CC(O)C1)C2=CC=CC=C2)C=CC=C3, belongs to isothiazole compound. In a article, author is Yan, Shunqi, introduce new discover of the category.
Isothiazole analogs were discovered as a novel class of active-site inhibitors of HCV NS5B polyrnerase. The best compound has an IC50 of 200 nM and EC50 of 100 nM, which is a significant improvement over the starting inhibitor (1). The X-ray complex structure of I with HCV NS5B was obtained at a resolution of 2.2 angstrom, revealing that the inhibitor is covalently linked with Cys 366 of the ‘primer-grip’. Furthermore, it makes considerable contacts with the C-terminus, P-loop, and more importantly, to the active-site of the enzyme. The uniqueness of this binding mode offers a new insight for the rational design of novel inhibitors for HCV NS5B polymerase. (c) 2006 Elsevier Ltd. All rights reserved.
Electric Literature of 18621-17-5, Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. I hope my blog about 18621-17-5 is helpful to your research.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com