Chemical Research Letters, April 2021. Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 121-89-1, Name is 3′-Nitroacetophenone, molecular formula is C8H7NO3, Category: isothiazole, belongs to isothiazole compound, is a common compound. In a patnet, author is BAGGI, P, once mentioned the new application about 121-89-1.
3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide(3) readily reacts with oxazolones 2 and munchnones 7 affording with satisfactory yield 3-diethylamino-4,6-diaryl-3a,4-dihydro-3a-(4-methoxyphenyl)6aH-pyrrolo[3,4-d]isthiazole 1,1-dioxides 4 and 3-diethylamino-4,6-diaryl-5-alkyl-3a-(4-methoxyphenyl)-pyrrolo[3,4]isothiazole l,1-dioxides 8, respectively. The behaviour of the cycloadducts towards elevated temperatures and/or basic conditions was investigated. Under these conditions the primary products lost SO2 and diethylcyanamide affording 1-alkyl-2,3,5-triarylpyrroles 9 and 1H-2,3,5-triarylpyrroles 10. These latter were found to be better obtained through thermal decomposition of N-protected cycloadducts 8 and subsequent deprotecting the final pyrroles.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 121-89-1. Category: isothiazole.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com