New Advances in Chemical Research in 2021, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 209911-63-7, Name is 4′-(Dibromomethyl)-[1,1′-biphenyl]-2-carbonitrile, molecular formula is C14H9Br2N, belongs to isothiazole compound. In a document, author is Zhang, Xuqing, introduce the new discover, Recommanded Product: 4′-(Dibromomethyl)-[1,1′-biphenyl]-2-carbonitrile.
We have discovered a novel series of isothiazole-based phenylpropanoic acids as GPR120 agonists. Extensive structure activity relationship studies led to the discovery of a potent GPR120 agonist 4x, which displayed good EC50 values in both calcium and beta-arrestin assays. It also presented good pharmaceutical properties and a favorable PK profile. Moreover, it demonstrated in vivo antidiabetic activity in C57BL/6 DIO mice. Studies in WT and knockout DIO mice showed that it improved glucose handling during an OGTT via GPR120. Overall, 4x possessed promising antidiabetic effect and good safety profile to be a development candidate.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 209911-63-7. Recommanded Product: 4′-(Dibromomethyl)-[1,1′-biphenyl]-2-carbonitrile.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com