Chemical Research Letters, April 2021. With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation we’ve spent the past two centuries establishing. 35271-74-0, Name is 3-(4-Chlorophenyl)pentanedioic acid, molecular formula is C11H11ClO4, Application In Synthesis of 3-(4-Chlorophenyl)pentanedioic acid, belongs to isothiazole compound, is a common compound. In a patnet, author is Larson, Gary, once mentioned the new application about 35271-74-0.
A series of isothiazole carboxamidine compounds were synthesized and discovered as novel and selective inhibitors for Chk2. They are not active against the related Chk1 kinase. The structure-activity relationship studies were performed on the scaffold, and enzymatic kinetic analysis showed they are simple ATP competitive inhibitors with K-i values as low as 11 nM for Chk2. Computer modeling studies were employed to comprehend the mechanism of action and SAR of these compounds. (c) 2006 Elsevier Ltd. All rights reserved.
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 35271-74-0, Application In Synthesis of 3-(4-Chlorophenyl)pentanedioic acid.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com