Chemical Research Letters, April 2021. With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation we’ve spent the past two centuries establishing. 555-16-8, Name is 4-Nitrobenzaldehyde, molecular formula is C7H5NO3, SDS of cas: 555-16-8, belongs to isothiazole compound, is a common compound. In a patnet, author is MELIKIAN, A, once mentioned the new application about 555-16-8.
Ten analogs of muscimol and thiomuscimol in which the amino function was delocalized in an amidinic system were prepared by N2 alkylation of 6-aryl-3-aminopyridazines with (chloromethyl) isoxazole or (chloromethyl)isothiazole derivatives. These muscimol and thiomuscimol derivatives show potent binding properties for GABA-A receptors (they displace [H-3]GABA and [H-3]gabazine) and provoke convulsions after iv injections. They fit well with the model pharmacophore proposed by our group for the GABA-A antagonists and show similar structure-activity profiles to that of the pyridazinyl-GABAs.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. In my other articles, you can also check out more blogs about 555-16-8. SDS of cas: 555-16-8.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com