Chemical Research Letters, April 2021. With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation we’ve spent the past two centuries establishing. 2307-69-9, Name is Isopropyl 4-methylbenzenesulfonate, molecular formula is C10H14O3S, Application of 2307-69-9, belongs to isothiazole compound, is a common compound. In a patnet, author is Nakae, Koichi, once mentioned the new application about 2307-69-9.
Natural products have contributed to the elucidation of biological mechanisms as well as drug discovery research. Even now, the expectation for natural products is undiminished. We screened prostaglandin release inhibitors that had no effect on in vitro cyclooxygenase activity derived from natural product sources and discovered pronqodine A. Using spectral analysis and total synthesis, the structure of pronqodine A was shown to be a benzo[d]isothiazole-4,7-dione analogue. Evaluation of the biological activity of pronqodine A revealed that the NAD(P)H dehydrogenase quinone 1 (NQO1) converted pronqodine A into a two-electron reductive form. The reductive form underwent autoxidation and reversed to its native form immediately with the generation of reactive oxygen species. Further investigations proved that pronqodine A inhibited cyclooxygenase enzyme activity only in the presence of NQO1. Pronqodine A acts as a potential bioreductive compound, inhibiting prostaglandin release in selectively activated NQO1-expressing cells.
Application of 2307-69-9, Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.I hope my blog about 2307-69-9 is helpful to your research.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com