Chemical Research Letters, April 2021. Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 611-70-1, Name is Isobutyrophenone, molecular formula is C10H12O, HPLC of Formula: https://www.ambeed.com/products/611-70-1.html, belongs to isothiazole compound, is a common compound. In a patnet, author is Willby, Melisa J., once mentioned the new application about 611-70-1.
A major cause of tuberculosis (TB) resistance to the aninoglycoside kanamycin (KAN) is the Mycobacterium tuberculosis (Mtb) acetyltransferase Eis. Upregulation of this enzyme is responsible for inactivation of KAN through acetylation. of its amino;groups. A 123 000 compound high-throughput screen (HTS);yielded several small-molecule Eis inhibitors 014 share an isothiazole S,S-dioxide hoteroeyelic core. TheSe were investigated for their, structure attiliity relationships.: Crystal structures of Eis in,complex with two potent inhibitorS show that these molecules are bound in the conformationally :adaptable aminoglycoSide binding site of the enzyme, thereby obstructing binding of KAN for acetylation. Importantly; we demonstrate that several Eis inhibitors, when used in combination with KAN against resistant Mtb, efficiently overcome KAN resistance. This approach paves the way:toward development of novel combination, thetapies against aminoglycoside-resistant TB.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. Interested yet? Keep reading other articles of 611-70-1, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/611-70-1.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com