Chemical Research Letters, April 2021. Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 104-57-4, Name is Benzyl formate, molecular formula is C8H8O2, Formula: https://www.ambeed.com/products/104-57-4.html, belongs to isothiazole compound, is a common compound. In a patnet, author is Mitchell, Miguel O., once mentioned the new application about 104-57-4.
The chalcogen bond, the noncovalent, electrostatic attraction between covalently bonded atoms in group 16 and Lewis bases, is present in protein-ligand interactions based on X-ray structures deposited in the Protein Data Bank (PDB). Discovering protein-ligand chalcogen bonding in the PDB employed a strategy that focused on searching the database for protein complexes of five-membered, heterocyclic ligands containing endocyclic sulfur with endo electron-withdrawing groups (isothiazoles; thiazoles; 1,2,3-, 1,2.4-, 1,2,5-, 1,3,4-thiadiazoles) and thiophenes with exo electron-withdrawing groups, e.g., 2-chloro, 2-bromo, 2-amino, 2-alkylthio. Out of 930 ligands investigated, 33 or 3.5% have protein-ligand S-O interactions of which 31 are chalcogen bonds and two appear to be S-HO hydrogen bonds. The bond angles for some of the chalcogen bonds found in the PDB are less than 90 degrees, and an electrostatic model is proposed to explain this phenomenon.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 104-57-4. Formula: https://www.ambeed.com/products/104-57-4.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com