Chemical Research Letters, April 2021. Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 66-77-3, Name is 1-Naphthaldehyde, molecular formula is C11H8O, Name: 1-Naphthaldehyde, belongs to isothiazole compound, is a common compound. In a patnet, author is Dyachenko, Maksim S., once mentioned the new application about 66-77-3.
The reactivity of the 4-amino-2,3-dihydro-1H-lambda 1(6)-isothiazole-1,1-dioxide (beta-amino-gamma-sultam) framework has not been studied sufficiently. Here we describe the chemical properties of this heterocyclic system toward electrophiles on spiranic and non-spiranic substrates. A variety of C-electrophiles (acetic anhydride, benzoyl chloride, DMFDMA, 4,4-dimethoxybutan-2-one) and heteroatom electrophiles (bromine, nitrosyl acetate) have been explored. Both the C-5 and 4-amino positions of the beta-amino-gamma-sultam system are able to undergo electrophilic reactions. Heteroatom electrophiles attack the C-5 position, whereas carbo-electrophiles affect the amino group. beta-Amino-gamma-sultams also were used as starting compounds for the synthesis of 6- or 7-substituted 1 lambda(6)-isothiazolo[4,5-b]pyridine-1,1-dioxides through condensation reaction and palladium-catalyzed oxidative coupling.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 66-77-3. Name: 1-Naphthaldehyde.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com