As a common heterocyclic compound, it belongs to isothiazole compound, name is 3-Piperazinobenzisothiazole hydrochloride, and cas is 87691-88-1, its synthesis route is as follows.
A heterogeneous mix of 6-(chloromethylcarbonyl)-4,4,8-trimethyl-3,4-dihydro-1H-quinolin-2-one (2.200g, 8.739mmole, 1.0eq), sodium carbonate (1.158g, 10.924mmole, 1.25 eq), sodium iodide (0.131 g, 0.874mmole, cat.), and added 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (3.353g, 13.110mmole, 1.5eq) in acetonitrile (35ml) was heated to 150C under microwave assistance for 30min. The reaction was diluted with H2O (100ml), CH2CI2 (100ml) and the layers separated. The aqueous layer was extracted with CH2Cl2 (2x, 50ml) and the organic layer dried over magnesium sulfate (MgSO4), concentrated, and the residue purified by MPLC (25 % EA/CH2CI2 – 50 % EA gradient over 20min and hold for 20min – 100 % EA gradient over 20min). The title compound was obtained as a white crystalline solid in 63 % yield with 30 % recovered starting material (6-(2-chloro-ethyl)-4,4,8-trimethyl-3,4-dihydro-1H-quinolin-2-one). 1H NMR (400 MHz, CDCl3) delta 7.90 (d, 1H, J = 7.94 Hz), 7.80 (d, 1H, J = 7.94 Hz), 7.46 (t, 1H, J = 7.94 Hz), 7.34 (t, 1H, J = 7.94 Hz), 7.02 (s, 1H), 6.91 (s, 1H), 4.78 (s, 1H), 3.69-3.55 (m, 4H), 2.86-2.59 (m, 8H), 2.45 (s, 2H), 2.21 (s, 3H), 1.30 (s, 6H)
87691-88-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,87691-88-1 ,3-Piperazinobenzisothiazole hydrochloride, other downstream synthetic routes, hurry up and to see
Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/26864; (2004); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com