New research progress on 91-10-1 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 91-10-1, Name is 2,6-Dimethoxyphenol, formurla is C8H10O3. In a document, author is PINIZZOTTO, MR, introducing its new discovery. SDS of cas: 91-10-1.
The in vitro effects of four isothiazoles [5,5′-diphenyl-3,3′-diisothiazole disulfide, 5-phenyl-3-mercapto-isothiazole, 5,5′-(4-chlorophenyl)-3,3′-diisothiazole disulfide, and 5-(4-chlorophenyl)-3-mercapto-isothiazole] on poliovirus type 1 were studied. The derivatives tested demonstrated remarkable viral inhibition, with a higher selectivity index than the previously studied iminodithiole precursors. Under one-step growth conditions, all the isothiazole derivatives caused the greatest activity if added during or after (within 1 h) pollovirus adsorption. These data suggest interference with early events of viral replication. [5-H-3]Uridine incorporation into RNA showed that the compounds tested reduced pollovirus RNA synthesis, which was completely shut off after 2 h of incubation and reduced by 50-60% after 4 h. Also, pretreatment of the cell cultures with the compounds for 24 h caused a substantial inhibition of viral replication. The data suggest that the four isothiazole derivatives may have a multi-step antiviral mode of action different from their iminodithiole precursors.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 91-10-1. SDS of cas: 91-10-1.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com