Can You Really Do Chemisty Experiments About C26H42O2

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. Interested yet? Keep reading other articles of 58446-52-9, you can contact me at any time and look forward to more communication. Computed Properties of https://www.ambeed.com/products/58446-52-9.html.

New research progress on 58446-52-9 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 58446-52-9, Name is 1-Phenylicosane-1,3-dione, formurla is C26H42O2. In a document, author is Kiselyov, Alex S., introducing its new discovery. Computed Properties of https://www.ambeed.com/products/58446-52-9.html.

A series of novel 1,3,4-oxadiazole derivatives based on structural and electronic overlap with combretastatins have been designed and synthesized. Initially, we tested all new compounds in vivo using the phenotypic sea urchin embryo assay to yield a number of agents with anti-proliferative, anti-mitotic, and microtubule destabilizing activities. The experimental data led to identification of 1,3,4-oxadiazole derivatives with isothiazole (5-8) and phenyl (9-12) pharmacophores featuring activity profiles comparable to that of combretastatins, podophyllotoxin and nocodazole. Cytotoxic effects of the two lead molecules, namely 6 and 12, were further confirmed and evaluated by conventional assays with the A549 human cancer cell line including cell proliferation, cell cycle arrest at the G2/M phase, cellular microtubule distribution, and finally in vitro microtubule assembly with purified tubulin. The modeling results using 3D similarity (ROCS) and docking (FRED) correlated well with the observed activity of the molecules. Docking data suggested that the most potent molecules are likely to target the colchicine binding site. (C) 2010 Elsevier Masson SAS. All rights reserved.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. Interested yet? Keep reading other articles of 58446-52-9, you can contact me at any time and look forward to more communication. Computed Properties of https://www.ambeed.com/products/58446-52-9.html.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com