New discoveries in chemical research and development in 2021, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 104-66-5, Name is 1,2-Diphenoxyethane, SMILES is C1(OCCOC2=CC=CC=C2)=CC=CC=C1, in an article , author is Greig, IR, once mentioned of 104-66-5, Safety of 1,2-Diphenoxyethane.
[GRAPHICS] Substituted 2,3,3a,4,5,7a-hexahydrobenzo[D]isothiazole 1,1-dioxides and 3,4,4a,5,6,8a-hexahydro-2H-benzo[e][1,2]thiazine 1,1-dioxides, novel cyclic sulfonamides, were synthesized by the thermal Diels-Alder reaction of triene derivatives of buta-1,3-diene 1-sulionic acid amide, The stereochemical outcome of the reaction was determined by NMR spectroscopy and X-ray crystallographic analysis. This chemistry has been used for the synthesis of 2-(4-chlorobenzyl)-5-(1H-imidazol-4-yl)-2,3,3a,4,5,7a-hexahydrobenzo[d]isothiazole 1,1-dioxide, a histamine H-3 receptor antagonist.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 104-66-5. Safety of 1,2-Diphenoxyethane.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com