New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis,and research on the structure and performance of functional materials. 122-75-8, Name is N1,N2-Dibenzylethane-1,2-diamine diacetate, molecular formula is C20H28N2O4, belongs to isothiazole compound. In a document, author is GAROZZO, A, introduce the new discover, Computed Properties of https://www.ambeed.com/products/122-75-8.html.
In this report we describe the antiviral activity of 5,5′-diphenyl-3,3’diisothiazole disulfide (DID) and discuss its mode of action. DID selectively inhibits the replication of poliovirus type 1 (therapeutic index = 255) by affecting some early process of the virus growth cycle. The compound does not interfere with adsorption and internalization of virus to HEp-2 cells, nor with uncoating of the viral RNA. However, no viral RNA synthesis occurs after 2 h postinfection in the presence of 50 mu M DID. Thus, we investigated some molecular events in poliovirus replication occurring between uncoating and viral RNA synthesis. In our experimental design, we studied the activity of RNA polymerase complex isolated from HEp-2 infected cells in the presence or absence of DID. Our results showed that the RNA polymerase complex was formed in the presence of DID, On the contrary, DID markedly inhibited poliovirus RNA synthesis in a cell-free system using RNA polymerase complex isolated from infected cells. These findings indicate that DID may exert its antiviral activity by preventing viral RNA chain elongation via the inhibition of replicase activity and/or interfering with viral RNA polymerase complex.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 122-75-8. Computed Properties of https://www.ambeed.com/products/122-75-8.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com