New Advances in Chemical Research in 2021. Synthetic Route of 552-63-6, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 552-63-6, Name is 3-Hydroxy-2-phenylpropanoic acid, SMILES is O=C(O)C(C1=CC=CC=C1)CO, belongs to isothiazole compound. In a article, author is Christoforou, IC, introduce new discover of the category.
3,5-Dichloroisothiazole-4-carbonitrile 1 reacts with aryl- and methylboronic acids to give in high yields the 3-chloro-5-(aryl and methyl)-isothiazole-4-carbonitrile 2 regiospecifically. The reaction was optimized with respect to base, phase transfer agent and palladium catalyst. Suzuki coupling at C-5 was also achieved in high yield using potassium phenyltrifluoroborate. The regiospecificity of either coupling method is maintained with 3,5-dibromoisothiazole-4-carbonitrile 4 to give exclusively 3-bromo-5-phenylisothiazole-4-carbonitrile 5. Suzuki cross-coupling conditions applied to 3-chloro-5-phenylisothiazole-4-carbonitrile 2a gave 3-phenoxy-5-phenylisothiazole-4-carbonitrite 6, which was prepared independently, and not the 3-phenyl derivative. All isothiazole products were fully characterized.
Synthetic Route of 552-63-6, Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.I hope my blog about 552-63-6 is helpful to your research.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com