New Advances in Chemical Research in 2021, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1504-58-1, Name is 3-Phenylprop-2-yn-1-ol, molecular formula is C9H8O, belongs to isothiazole compound. In a document, author is Yan, Shunqi, introduce the new discover, COA of Formula: https://www.ambeed.com/products/1504-58-1.html.
Isothiazole analogs were discovered as a novel class of active-site inhibitors of HCV NS5B polyrnerase. The best compound has an IC50 of 200 nM and EC50 of 100 nM, which is a significant improvement over the starting inhibitor (1). The X-ray complex structure of I with HCV NS5B was obtained at a resolution of 2.2 angstrom, revealing that the inhibitor is covalently linked with Cys 366 of the ‘primer-grip’. Furthermore, it makes considerable contacts with the C-terminus, P-loop, and more importantly, to the active-site of the enzyme. The uniqueness of this binding mode offers a new insight for the rational design of novel inhibitors for HCV NS5B polymerase. (c) 2006 Elsevier Ltd. All rights reserved.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. In my other articles, you can also check out more blogs about 1504-58-1. COA of Formula: https://www.ambeed.com/products/1504-58-1.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com