New research progress on 35271-74-0 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 35271-74-0, Name is 3-(4-Chlorophenyl)pentanedioic acid, formurla is C11H11ClO4. In a document, author is Larson, Gary, introducing its new discovery. Application In Synthesis of 3-(4-Chlorophenyl)pentanedioic acid.
A series of isothiazole carboxamidine compounds were synthesized and discovered as novel and selective inhibitors for Chk2. They are not active against the related Chk1 kinase. The structure-activity relationship studies were performed on the scaffold, and enzymatic kinetic analysis showed they are simple ATP competitive inhibitors with K-i values as low as 11 nM for Chk2. Computer modeling studies were employed to comprehend the mechanism of action and SAR of these compounds. (c) 2006 Elsevier Ltd. All rights reserved.
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 35271-74-0, Application In Synthesis of 3-(4-Chlorophenyl)pentanedioic acid.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com