Chemical Research Letters, April 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 99-75-2, Name is Methyl 4-methylbenzoate, molecular formula is C9H10O2, Recommanded Product: Methyl 4-methylbenzoate, belongs to isothiazole compound, is a common compound. In a patnet, author is Willby, Melisa J., once mentioned the new application about 99-75-2.
A major cause of tuberculosis (TB) resistance to the aninoglycoside kanamycin (KAN) is the Mycobacterium tuberculosis (Mtb) acetyltransferase Eis. Upregulation of this enzyme is responsible for inactivation of KAN through acetylation. of its amino;groups. A 123 000 compound high-throughput screen (HTS);yielded several small-molecule Eis inhibitors 014 share an isothiazole S,S-dioxide hoteroeyelic core. TheSe were investigated for their, structure attiliity relationships.: Crystal structures of Eis in,complex with two potent inhibitorS show that these molecules are bound in the conformationally :adaptable aminoglycoSide binding site of the enzyme, thereby obstructing binding of KAN for acetylation. Importantly; we demonstrate that several Eis inhibitors, when used in combination with KAN against resistant Mtb, efficiently overcome KAN resistance. This approach paves the way:toward development of novel combination, thetapies against aminoglycoside-resistant TB.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. In my other articles, you can also check out more blogs about 99-75-2. Recommanded Product: Methyl 4-methylbenzoate.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com