New research progress on 581-96-4 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 581-96-4, Name is 2-(Naphthalen-2-yl)acetic acid, formurla is C12H10O2. In a document, author is Vicini, Paola, introducing its new discovery. Quality Control of 2-(Naphthalen-2-yl)acetic acid.
Several benzo[d]isothiazole hydrazones have been evaluated for their potential antiretroviral activity. Since a number of these compounds were found to be inactive against viruses, but showed cytotoxicity at micromolar concentrations against the human CD4(+) lymphocytes (MT-4) that were used to support HIV-1 growth, they were further tested for antiproliferative activity. The compounds resulted as being cytotoxic for MT-4 cells and new derivatives which were rationally designed and synthesized, were tested for antiproliferative activity against several leukaemia and solid, tumour cell lines. In addition, these compounds were evaluated against normal cell lines. Compound 2h proved to be the most active compound and the fragment -CO-NH-N=CH-2-hydroxyphenyl was identified as being very important for biological activity, suggesting intramolecular, hydrogen bond formation or favourable mutual disposition between two important centres in the pharmacophore. H-1-NMR spectra have been explained with the support of a conformational analysis. (c) 2006 Elsevier SAS. All rights reserved.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. In my other articles, you can also check out more blogs about 581-96-4. Quality Control of 2-(Naphthalen-2-yl)acetic acid.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com