New research progress on 151-05-3 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 151-05-3, Name is 2-Methyl-1-phenylpropan-2-yl acetate, formurla is C12H16O2. In a document, author is Fisher, Matthew J., introducing its new discovery. Quality Control of 2-Methyl-1-phenylpropan-2-yl acetate.
The disclosed 3-phenyl-5-isothiazole carboxamides are potent allosteric antagonists of mGluR1 with generally good selectivity relative to the related group 1 receptor mGluR5. Pharmacokinetic properties of a member of this series (1R,2R)-N-(3-(4-methoxyphenyl)-4-methylisothiazol-5-yl)-2-methylcyclopropanecarboxamide (14) are good, showing acceptable plasma and brain exposure after oral dosing. Oral administration of isothiazole 14 gave robust activity in the formalin model of persistent pain which correlated with CNS receptor occupancy. (C) 2012 Elsevier Ltd. All rights reserved.
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 151-05-3, Quality Control of 2-Methyl-1-phenylpropan-2-yl acetate.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com