New Advances in Chemical Research in 2021, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 503-29-7, Name is Azetidine, molecular formula is C3H7N, belongs to isothiazole compound. In a document, author is Zakharova, VM, introduce the new discover, Application In Synthesis of Azetidine.
Rhodium(II)-catalyzed decomposition of fluorinated diazo diketones in the presence of isothiazole-3(2H)-one 1,1-dioxides offers a chemoselective and useful tool for O-functionalization of their C=O groups by interaction with transient fluorine-containing Rh-II-diketocarbenoids. The resulting O-alkylimidates of isothiazole 1,1-dioxides, bearing (trifluoromethyl)acetyl groups, easily react with traces of H2O giving rise to stable hydrates of the perfluoroacetyl groups. No O -> N isomerization of O-alkylimidates (similar to the Lander-Chapman rearrangement) was observed under the reaction conditions studied.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 503-29-7, Application In Synthesis of Azetidine.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com