Never Underestimate The Influence Of 3-(4-Chlorophenyl)pentanedioic acid

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 35271-74-0, Name is 3-(4-Chlorophenyl)pentanedioic acid, molecular formula is C11H11ClO4. In an article, author is Shimada, Kazuaki,once mentioned of 35271-74-0, Category: isothiazole.

One-Step Synthesis of 2-Alkenecarbodithioate Esters from Substituted Propargyl Ethers, and Their Conversion into Isothiazole Ring through a [4+1] Type Oxidative Ring Closure

Treatment of substituted propargyl methyl ethers with a base and elemental sulfur in the presence of a thiolate ion afforded 2-alkenecarbodithioate esters in good yields. The reaction is assumed to proceed through a pathway involving in situ generation of propadienethione intermediates. Further conversion of 2-alkenecarbodithioate esters into 2,3-dihydroisothiazoles were efficiently performed by treating with chloramine-T through a [4+1] type oxidative ring closure via thiocarbonyl S-tosylimides.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com