Chemistry, like all the natural sciences, Quality Control of 2-(Naphthalen-2-yl)acetic acid, begins with the direct observation of nature¡ª in this case, of matter.581-96-4, Name is 2-(Naphthalen-2-yl)acetic acid, SMILES is O=C(O)CC1=CC=C2C=CC=CC2=C1, belongs to isothiazole compound. In a document, author is Vicini, Paola, introduce the new discover.
Synthesis and antiproliferative activity of benzo[d]isothiazole hydrazones
Several benzo[d]isothiazole hydrazones have been evaluated for their potential antiretroviral activity. Since a number of these compounds were found to be inactive against viruses, but showed cytotoxicity at micromolar concentrations against the human CD4(+) lymphocytes (MT-4) that were used to support HIV-1 growth, they were further tested for antiproliferative activity. The compounds resulted as being cytotoxic for MT-4 cells and new derivatives which were rationally designed and synthesized, were tested for antiproliferative activity against several leukaemia and solid, tumour cell lines. In addition, these compounds were evaluated against normal cell lines. Compound 2h proved to be the most active compound and the fragment -CO-NH-N=CH-2-hydroxyphenyl was identified as being very important for biological activity, suggesting intramolecular, hydrogen bond formation or favourable mutual disposition between two important centres in the pharmacophore. H-1-NMR spectra have been explained with the support of a conformational analysis. (c) 2006 Elsevier SAS. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 581-96-4. Quality Control of 2-(Naphthalen-2-yl)acetic acid.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com