Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.555-16-8, Name is 4-Nitrobenzaldehyde, SMILES is O=CC1=CC=C([N+]([O-])=O)C=C1, belongs to isothiazole compound. In a document, author is Kang, YK, introduce the new discover, Name: 4-Nitrobenzaldehyde.
Synthesis and biological evaluation of novel 1 beta-methylcarbapenems with isothiazoloethenyl side chains
The synthesis of novel 1beta-methylcarbapenems la,b bearing isothiazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. Especially, 5-isothiazole derivative la exhibited excellent DHP-I stability and advanced pharmacokinetics profiles, compared to 5-isoxazole derivative 2, imipenem, and meropenem. (C) 2002 Elsevier Science Ltd. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 555-16-8. Name: 4-Nitrobenzaldehyde.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com