A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 555-16-8, Name is 4-Nitrobenzaldehyde, molecular formula is C7H5NO3. In an article, author is MELIKIAN, A,once mentioned of 555-16-8, Category: isothiazole.
CONDENSATION OF MUSCIMOL OR THIOMUSCIMOL WITH AMINOPYRIDAZINES YIELDS GABA-A ANTAGONISTS
Ten analogs of muscimol and thiomuscimol in which the amino function was delocalized in an amidinic system were prepared by N2 alkylation of 6-aryl-3-aminopyridazines with (chloromethyl) isoxazole or (chloromethyl)isothiazole derivatives. These muscimol and thiomuscimol derivatives show potent binding properties for GABA-A receptors (they displace [H-3]GABA and [H-3]gabazine) and provoke convulsions after iv injections. They fit well with the model pharmacophore proposed by our group for the GABA-A antagonists and show similar structure-activity profiles to that of the pyridazinyl-GABAs.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com