The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Product Details of 555-16-8, 555-16-8, Name is 4-Nitrobenzaldehyde, SMILES is O=CC1=CC=C([N+]([O-])=O)C=C1, in an article , author is Lu, Yuelie, once mentioned of 555-16-8.
An efficient one-pot construction of substituted pyrimidinones
A concise, scaleable synthesis of building block 10 for p38 kinase inhibitor B is described. The key step is the one-pot construction of 5-aryl-3-metbyl-2-methylsulfanyl-6-pyridin-4-yi-3H-pyrimidin-4-one 4 from arylacetic acid ethyl ester 1. Subsequent hydrolysis of the thiomethyl group to the hydroxy group and chlorination provided the key intermediate, 2-chloro-3-methyl-6-pyridin-4-yl-5-aryl-3Hpyrimidin-4-one 10. This class of reactive building blocks enabled the rapid evaluation of a variety of side chains at the 2-position of the pyrimidinone in SAR studies of inhibitors of p38 MAP kinase. (c) 2006 Elsevier Ltd. All rights reserved.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 555-16-8, you can contact me at any time and look forward to more communication. Product Details of 555-16-8.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com