The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Quality Control of Sulfonyldibenzene, 127-63-9, Name is Sulfonyldibenzene, SMILES is O=S(C1=CC=CC=C1)(C2=CC=CC=C2)=O, in an article , author is Bunch, L, once mentioned of 127-63-9.
Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: Application to the synthesis of thioibotenic acid
Direct functionalization of the 3-oxygenated isothiazole heteroaromatic parental system has not yet been reported in the literature. Here, we report the first regioselective lithiation of the 5-position of 3-(benzyloxy)isothiazole (4) using LDA in diethyl ether. The versatility of the methodology was explored by quenching with a variety of electrophiles to give the desired products 7a,b,d-g in 54-68% yield. Only benzoylation aiming at the synthesis of 7c was unsuccessful. Furthermore, a highly convergent synthesis of thioibotenic acid (1), the sulfur analogue of the neurotoxic natural product ibotenic acid, was carried out.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 127-63-9, you can contact me at any time and look forward to more communication. Quality Control of Sulfonyldibenzene.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com