Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mishra, Vaibhav, once mentioned the application of 114772-54-2, Name is 4′-(Bromomethyl)-[1,1′-biphenyl]-2-carbonitrile, molecular formula is C14H10BrN, molecular weight is 272.14, MDL number is MFCD00671503, category is isothiazole. Now introduce a scientific discovery about this category, Quality Control of 4′-(Bromomethyl)-[1,1′-biphenyl]-2-carbonitrile.
Synthesis and antimicrobial activity of 1-(benzo[b]thiophen-4-yl)-4-(2-(oxo, hydroxyl, and fluoro)-2-phenylethyl)piperazine and 1-(benzo[d]isothiazole-3-yl)-4-(2-(oxo, hydroxy, and fluoro)-2-phenylethyl)piperazine derivatives
Twenty-two compounds in a series of 1-(benzo[b]thiophen-4-yl)-4-(2-(oxo, hydroxy, and fluoro)-2-phenylethyl) piperazine and 1-(benzo[d]isothiazole-3-yl)-4-(2-(oxo, hydroxy, and fluoro)-2-phenylethyl)-piperazine derivatives were synthesized through nucleophilic substitution reaction of phenacyl bromides with hetero arylpiperazine, reduction, and then fluorination. Compound K2 showed potent activity against gram-negative bacterial stain P. aeruginosa with minimum inhibitory concentration (MIC) value of 12.5 mu g/mL. This compound showed better inhibitory activity than the standard drug chloramphenicol. K4 against S. aureus, H2 against P. aeruginosa, and F4 against E. coli showed good inhibitory activity with MIC values of 62.5 mu g/mL. Compounds K1, K2, K4, K8, F1, and F3 showed good inhibitory activity against fungal stain C. albicans with MIC values of 250 mu g/mL. The crystal structure of F1 was determined by single-crystal XRD (CCDC 1832090).
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 114772-54-2, Quality Control of 4′-(Bromomethyl)-[1,1′-biphenyl]-2-carbonitrile.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com