Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 92-91-1, Name is 1-([1,1′-Biphenyl]-4-yl)ethanone, molecular formula is C14H12O. In an article, author is Bunch, L,once mentioned of 92-91-1, Computed Properties of C14H12O.
Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: Application to the synthesis of thioibotenic acid
Direct functionalization of the 3-oxygenated isothiazole heteroaromatic parental system has not yet been reported in the literature. Here, we report the first regioselective lithiation of the 5-position of 3-(benzyloxy)isothiazole (4) using LDA in diethyl ether. The versatility of the methodology was explored by quenching with a variety of electrophiles to give the desired products 7a,b,d-g in 54-68% yield. Only benzoylation aiming at the synthesis of 7c was unsuccessful. Furthermore, a highly convergent synthesis of thioibotenic acid (1), the sulfur analogue of the neurotoxic natural product ibotenic acid, was carried out.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com