Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 35271-74-0, Name is 3-(4-Chlorophenyl)pentanedioic acid, molecular formula is C11H11ClO4. In an article, author is Larson, Gary,once mentioned of 35271-74-0, Recommanded Product: 35271-74-0.
Identification of novel, selective and potent Chk2 inhibitors
A series of isothiazole carboxamidine compounds were synthesized and discovered as novel and selective inhibitors for Chk2. They are not active against the related Chk1 kinase. The structure-activity relationship studies were performed on the scaffold, and enzymatic kinetic analysis showed they are simple ATP competitive inhibitors with K-i values as low as 11 nM for Chk2. Computer modeling studies were employed to comprehend the mechanism of action and SAR of these compounds. (c) 2006 Elsevier Ltd. All rights reserved.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com