Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, SDS of cas: 114772-54-2114772-54-2, Name is 4′-(Bromomethyl)-[1,1′-biphenyl]-2-carbonitrile, SMILES is C1=CC=CC(=C1C2=CC=C(C=C2)CBr)C#N, belongs to isothiazole compound. In a article, author is PINIZZOTTO, MR, introduce new discover of the category.
INVITRO ANTIVIRAL ACTIVITY OF 4 ISOTHIAZOLE DERIVATIVES AGAINST POLIOVIRUS TYPE-1
The in vitro effects of four isothiazoles [5,5′-diphenyl-3,3′-diisothiazole disulfide, 5-phenyl-3-mercapto-isothiazole, 5,5′-(4-chlorophenyl)-3,3′-diisothiazole disulfide, and 5-(4-chlorophenyl)-3-mercapto-isothiazole] on poliovirus type 1 were studied. The derivatives tested demonstrated remarkable viral inhibition, with a higher selectivity index than the previously studied iminodithiole precursors. Under one-step growth conditions, all the isothiazole derivatives caused the greatest activity if added during or after (within 1 h) pollovirus adsorption. These data suggest interference with early events of viral replication. [5-H-3]Uridine incorporation into RNA showed that the compounds tested reduced pollovirus RNA synthesis, which was completely shut off after 2 h of incubation and reduced by 50-60% after 4 h. Also, pretreatment of the cell cultures with the compounds for 24 h caused a substantial inhibition of viral replication. The data suggest that the four isothiazole derivatives may have a multi-step antiviral mode of action different from their iminodithiole precursors.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 114772-54-2. SDS of cas: 114772-54-2.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com