Chemistry, like all the natural sciences, Computed Properties of C8H13NO3, begins with the direct observation of nature¡ª in this case, of matter.398489-26-4, Name is tert-Butyl 3-oxoazetidine-1-carboxylate, SMILES is CC(OC(=O)N1CC(=O)C1)(C)C, belongs to isothiazole compound. In a document, author is Amirhamzeh, Amirali, introduce the new discover.
Synthesis and docking study of diaryl-isothiazole and 1,2,3-thiadiazole derivatives as potential neuroprotective agents
Neuroinflammation has been implicated in pathophysiology of many neurodegenerative diseases. The p38 MAP kinase signaling pathway and COX-1 have active roles in initiation and perpetuation of neuroinflammatory process which have deteriorating effects on neurons. In order to develop new anti-neuroinflammatory compounds some 4-aryl-5-(methylthiophen-2-yl) isothiazoles and 5-aryl-4-(methylthiophen-2-yl)-1,2,3-thiadiazoles were synthesized. Docking studies have revealed that these structures could be potential mutual inhibitors of p38 alpha and COX-1 and could be considered for neuroprotective effects. In order to assess CNS penetrability of these compounds, a QSAR model of blood-brain barrier penetration has been developed and LogBB of compounds has been predicted. All compounds showed LogBB as greater than zero which indicates their potential CNS penetrability.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 398489-26-4. Computed Properties of C8H13NO3.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com