Reference of 66-98-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 66-98-8, Name is [1,1′-Biphenyl]-4,4′-dicarbaldehyde, SMILES is O=CC1=CC=C(C2=CC=C(C=O)C=C2)C=C1, belongs to isothiazole compound. In a article, author is Melagraki, Georgia, introduce new discover of the category.
In Silico Exploration for Identifying Structure-Activity Relationship of MEK Inhibition and Oral Bioavailability for Isothiazole Derivatives
In this study, quantitative structure-activity/property models are developed for modeling and predicting both MEK inhibitory activity and oral bioavailability of novel isothiazole-4-carboxamidines. The models developed are thoroughly discussed to identify the key components that influence the inhibitory activity and oral bioavailability of the selected compounds. These selected descriptors serve as a first guideline for the design of novel and potent MEK inhibitors with desired ADME properties.
Reference of 66-98-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 66-98-8.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com