103-60-6, Name is 2-Phenoxyethyl isobutyrate, molecular formula is C12H16O3, belongs to isothiazole compound, is a common compound. In a patnet, author is MALLERON, JL, once mentioned the new application about 103-60-6, Application In Synthesis of 2-Phenoxyethyl isobutyrate.
NAPHTHOSULTAM DERIVATIVES – A NEW CLASS OF POTENT AND SELECTIVE 5-HT2 ANTAGONISTS
A series of 2-(aminoalkyl)naphth[1,8-cd]isothiazole 1,1-dioxides was synthesized and examined in various receptor binding tests. Most compounds demonstrated high affinity for the 5-HT2 receptor with moderate to high selectivity. A member of this series, compound 24 (RP 62203), displays high 5-HT2 receptor affinity (K(i) = 0.26 nM), which is respectively more than 100 and 1000 times higher than its affinity for alpha-1 (K(i) = 38 nM) and D2 (K(i) > 1000 nM) receptors. This compound is a potent orally effective and long lasting 5-HT2 antagonist in the mescaline-induced head-twitches test in mice and rats.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com