Let¡¯s face it, organic chemistry can seem difficult to learn, Product Details of 209911-63-7, Especially from a beginner¡¯s point of view. Like 209911-63-7, Name is 4′-(Dibromomethyl)-[1,1′-biphenyl]-2-carbonitrile, molecular formula is isothiazole, belongs to isothiazole compound. In a document, author is Zhang, Xuqing, introducing its new discovery.
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes
We have discovered a novel series of isothiazole-based phenylpropanoic acids as GPR120 agonists. Extensive structure activity relationship studies led to the discovery of a potent GPR120 agonist 4x, which displayed good EC50 values in both calcium and beta-arrestin assays. It also presented good pharmaceutical properties and a favorable PK profile. Moreover, it demonstrated in vivo antidiabetic activity in C57BL/6 DIO mice. Studies in WT and knockout DIO mice showed that it improved glucose handling during an OGTT via GPR120. Overall, 4x possessed promising antidiabetic effect and good safety profile to be a development candidate.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com