Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 100-18-5, Name is 1,4-Diisopropylbenzene, SMILES is CC(C1=CC=C(C(C)C)C=C1)C, belongs to isothiazole compound. In a document, author is Mitchell, Miguel O., introduce the new discover, Quality Control of 1,4-Diisopropylbenzene.
Discovering protein-ligand chalcogen bonding in the protein data bank using endocyclic sulfur-containing heterocycles as ligand search subsets
The chalcogen bond, the noncovalent, electrostatic attraction between covalently bonded atoms in group 16 and Lewis bases, is present in protein-ligand interactions based on X-ray structures deposited in the Protein Data Bank (PDB). Discovering protein-ligand chalcogen bonding in the PDB employed a strategy that focused on searching the database for protein complexes of five-membered, heterocyclic ligands containing endocyclic sulfur with endo electron-withdrawing groups (isothiazoles; thiazoles; 1,2,3-, 1,2.4-, 1,2,5-, 1,3,4-thiadiazoles) and thiophenes with exo electron-withdrawing groups, e.g., 2-chloro, 2-bromo, 2-amino, 2-alkylthio. Out of 930 ligands investigated, 33 or 3.5% have protein-ligand S-O interactions of which 31 are chalcogen bonds and two appear to be S-HO hydrogen bonds. The bond angles for some of the chalcogen bonds found in the PDB are less than 90 degrees, and an electrostatic model is proposed to explain this phenomenon.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 100-18-5 is helpful to your research. Quality Control of 1,4-Diisopropylbenzene.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com