Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Garozzo, A, once mentioned the application of 939-97-9, Name is 4-(tert-Butyl)benzaldehyde, molecular formula is C11H14O, molecular weight is 162.2283, MDL number is MFCD00035742, category is isothiazole. Now introduce a scientific discovery about this category, SDS of cas: 939-97-9.
Antirhinovirus activity of 3-methylthio-5-aryl-4-isothiazolecarbonitrile derivatives
A series of 3-methylthio-5-aryl-4-isothiazolecarbonitriles has been evaluated as anti rhinovirus agents against a panel. of 17 representative human rhinovirus (HRV) serotypes, belonging to both A and B groups. No anti rhinovirus activity was detected for 3-methylthio-5-phenyl-4-isothiazolecarbonitrile (IS-2). Isothiazole derivatives with bulky substituents (O-Bn or O-But groups) on the para position of the phenyl ring were the most effective compounds of this series. In fact, a reduction in virus-induced cytopathogenicity was demonstrated for the O-Bn substituted IS-50 compound against the majority (88%) of the rhinoviruses tested, whereas the compound with an O-Ts group (IS-44) was found to be a specific inhibitor of group B serotypes, exhibiting the lowest IC50 against HRVs type 2, 85 and 89. Our studies on the mechanism of action of IS-44 demonstrated that it prevents the thermal inactivation of HRV 2 infectivity, probably due to a conformational shift in the viral capsid and a decrease in affinity for the cellular receptor, resulting in an inhibition of attachment of the virions. (C) 2000 Elsevier Science B.V. All rights reserved.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 939-97-9, SDS of cas: 939-97-9.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com