One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 102-96-5, Name is (2-Nitrovinyl)benzene, formurla is C8H7NO2. In a document, author is Sipos, Attila, introducing its new discovery. Quality Control of (2-Nitrovinyl)benzene.
Synthesis and Pharmacological Evaluation of Thiazole and Isothiazole Derived Apomorphines
We have presented the synthesis of novel thiazolo-and isothiazolo-apomorphines 12-17 resulting-in part-from an unexpected isomerization step occurred during the acid-catalyzed rearrangement of precursor thiazolo-morphinandienes 3-5. These 2,3-disubstituted apomorphines represent a new group of A-ring substituted aporphines. The receptor binding studies revealed that with the exception of two derivatives all the tested compounds have limited affinity for dopamine-receptor subtypes. Functional calcium assay for the most active isothiazolo-apomorphine showed higher affinities for D-1 and D-2L subtypes. The docking of these ligands has been modelled to human D-2 and D-3 receptors. On the basis of the predicted models, we identified an important cation-p interaction for the binding of isothiazolo-apomorphine 16.
If you are hungry for even more, make sure to check my other article about 102-96-5, Quality Control of (2-Nitrovinyl)benzene.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com