Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 28348-53-0, Name is Sodium isopropylbenzenesulfonate, molecular formula is C9H11NaO3S. In an article, author is Amin, Kamelia M.,once mentioned of 28348-53-0, Recommanded Product: 28348-53-0.
EGFR tyrosine kinase targeted compounds: synthesis, docking study, and in vitro antitumor activity of some new quinazoline and benzo[d]isothiazole derivatives
The preparation of new quinazoline and benzo[d]isothiazole-based antitumor agents is described. The target compounds fall into three groups including the N-substituted derivatives 2a-d, the substituted amino derivatives 4-6a-d, and the dimeric compounds 7-9a,b. Docking study of the designed compounds into the ATP binding site of epidermal growth factor receptor (EGFR) tyrosine kinase was performed to compare the binding mode of these compounds to the known EGFR inhibitor, lapatinib. All compounds were tested, in vitro, for their activity against human mammary carcinoma cell line (MCF7) in which EGFR is highly expressed. All compounds showed significant growth inhibitory activity. The remarkable activity of the bis quinazoline derivative 8a (IC50 = 0.06 mu g/ml; 1.64 nmol/ml) is to be noted.
Interested yet? Keep reading other articles of 28348-53-0, you can contact me at any time and look forward to more communication. Recommanded Product: 28348-53-0.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com