In an article, author is SWAYZE, EE, once mentioned the application of 121-89-1, Product Details of 121-89-1, Name is 3′-Nitroacetophenone, molecular formula is C8H7NO3, molecular weight is 165.1461, MDL number is MFCD00007259, category is isothiazole. Now introduce a scientific discovery about this category.
THE SYNTHESIS OF SEVERAL IMIDAZO[4,5-D]ISOTHIAZOLES – DERIVATIVES OF A NEW RING-SYSTEM
Several derivatives of the new imidazo[4,5-d]isothiazole ring system have been synthesized from the appropriately substituted isothiazolediamines. The reaction of 3-methyl-4,5-diaminoisothiazole (4a) with diethoxy-methyl acetate gave a low yield of 3-methylimidazo[4,5-d]isothiazole (5a). However, the analogous reaction of 4,5-diaminoisothiazole (4b) with diethoxymethyl acetate failed to yield the parent imidazo[4,5-d]isothiazole ring system. The diamines 4a and 4b were readily cyclized with thiocarbonyldiimidazole to give the unstable thiones 6a and 6b, which were alkylated in situ to afford good yields of the corresponding 5-methylthioimidazo[4,5-d]isothiazoles 7a and 7b, respectively. Neither of these compounds could be reduced to the corresponding 5-unsubstituted derivatives via treatment with Raney nickel. To the best of our knowledge, this is the first report of the imidazo[4,5-d]isothiazole ring system.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com