Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 5-Methyl-2-phenylhex-2-enal, 21834-92-4, Name is 5-Methyl-2-phenylhex-2-enal, molecular formula is C13H16O, belongs to isothiazole compound. In a document, author is Bollinger, Sean R., introduce the new discover.
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu(4))
This work describes the discovery and characterization of novel 6-(1H-pyrazolo[4,3-b]pyridin-3-yl)amino-benzo[d]isothiazole-3-carboxamides as mGlu(4) PAMs. This scaffold provides improved metabolic clearance and CYP1A2 profiles compared to previously discovered mGlu(4) PAMs. From this work, 27o (VU6001376) was identified as a potent (EC50 = 50.1 nM, 50.5% GluMax) and selective mGlu(4) PAM with an excellent rat DMPK profile (in vivo rat CLP, = 3.1 mL/min/kg, t(1/2) = 445 min, CYP1A2 IC50 > 30 mu M). Compound 270 was also active in reversing haloperidol induced catalepsy in a rodent preclinical model of Parkinson’s disease.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 21834-92-4. Recommanded Product: 5-Methyl-2-phenylhex-2-enal.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com