Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Willby, Melisa J., once mentioned the application of 611-70-1, Name is Isobutyrophenone, molecular formula is C10H12O, molecular weight is 148.2017, MDL number is MFCD00008917, category is isothiazole. Now introduce a scientific discovery about this category, Recommanded Product: 611-70-1.
Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis
A major cause of tuberculosis (TB) resistance to the aninoglycoside kanamycin (KAN) is the Mycobacterium tuberculosis (Mtb) acetyltransferase Eis. Upregulation of this enzyme is responsible for inactivation of KAN through acetylation. of its amino;groups. A 123 000 compound high-throughput screen (HTS);yielded several small-molecule Eis inhibitors 014 share an isothiazole S,S-dioxide hoteroeyelic core. TheSe were investigated for their, structure attiliity relationships.: Crystal structures of Eis in,complex with two potent inhibitorS show that these molecules are bound in the conformationally :adaptable aminoglycoSide binding site of the enzyme, thereby obstructing binding of KAN for acetylation. Importantly; we demonstrate that several Eis inhibitors, when used in combination with KAN against resistant Mtb, efficiently overcome KAN resistance. This approach paves the way:toward development of novel combination, thetapies against aminoglycoside-resistant TB.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 611-70-1, Recommanded Product: 611-70-1.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com